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Mechanisms of cytotoxicity by NK cells

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Published by Academic Press in Orlando .
Written in English


  • Killer cells -- Congresses.,
  • Cell-mediated cytotoxicity -- Congresses.,
  • Cytotoxicity, Immunologic -- congresses.,
  • Immunity, Cellular -- congresses.,
  • Killer Cells, Natural -- immunology -- congresses.

Book details:

Edition Notes

Other titlesMechanisms of cytotoxicity by natural killer cells.
Statementedited by Ronald B. Herberman, Denis M. Callewaert.
ContributionsHerberman, Ronald B., 1940-, Callewaert, Denis M., International Workshop on NK Cells (3rd : 1984 : Oakland University)
LC ClassificationsQR185.8.K54 M43 1985
The Physical Object
Paginationxxiii, 669 p. :
Number of Pages669
ID Numbers
Open LibraryOL2557122M
ISBN 100123413702
LC Control Number85070441

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Mechanisms of Cytotoxicity by NK Cells is the resulting book of a workshop focused on the studies that enhance understanding of the basic mechanisms involved in the function and regulation of NK cells. The book presents the status of knowledge of the mechanisms responsible for the cytotoxic effects of NK cells and the regulation of their by: Mechanisms of cytotoxicity by NK cells. Orlando: Academic Press, (OCoLC) Online version: Mechanisms of cytotoxicity by NK cells. Orlando: Academic Press, (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors / Contributors: Ronald B Herberman; Denis M Callewaert. The symposium provided a forum for reviewing the progress that has been made in understanding the effector and regulatory mechanisms underlying natural and induced cell-mediated cytotoxicity. Topics covered range from the immunobiology of natural killer cells to the role of macrophages as regulator, accessory, and effector cells in cytotoxicity. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle .

NK cells kill target cells by either of two major mechanisms that require direct contact between NK cells and target cells. In the first pathway, cytoplasmic granule toxins, predominantly a membrane-disrupting protein known as perforin, and a family of structurally related serine proteases (granzymes) with various substrate specificities, are Cited by: MECHANISMS OF CYTOTOXICITY: MOLECULES AND PHENOMENA ASSOCIATED WITH EFFECTOR CELLS AND TARGET CELLS. Characterization of a Sulfatase From Granules of Natural Killer (NK) Cells (Andrew A. Amoscoto, Anne M. Brumfield, Stephanie B. Sansoni, Ronald B. Herberman, and WIlliam H. Chambers). Natural killer cell cytotoxic activity NK cells also initiate target cell apoptosis through the death receptor pathway [24]. Tumour necrosis factor (TNF) ligands expressed on NK cells bind to the Fas (CD95/Apo-1) and TNF-related apoptosis inducing ligand (TRAIL) on the target cell to induce apoptosis [29, 32]. Natural killer (NK) cells are part of the innate arm of the immune system. Their function is to eliminate aberrant cells, including virally infected and tumorigenic cells. For this purpose NK cells store cytotoxic proteins within secretory lysosomes, specialized exocytic organelles that are also known as lytic by:

Cytotoxicity is the general quality of being toxic to cells, and can be caused by chemical stimuli, exposure to other cells (NK or T cells for example), or physical/environmental conditions (radiation exposure, temperature or pressure extremes, etc.).Author: Tülay Aşkin Çelik. The First International Workshop on Mechanisms in Cell-Mediated Cytoxicity was held at Carry-Ie-Rouet, France, September , The Workshop brought together for the first time leading investiga­ tors in each of the principal areas of cell-mediated cytotoxicity, as well as experts in the area of complement-mediated cytoxicity. NK cells express high levels of CD16, while CD56bright NK cells are CD16 dim or negative16 (Figure 1). Adoptive Transfer of NK Cells to Target Tumors Their rapid killing and broad cytotoxicity make NK cells uniquely primed for use in adoptive therapy. In vitro, NK cells exert Figure 1. Mechanisms of NK-Mediated Cytotoxicity (A) Spontaneous File Size: KB. NK cells play an important role in host immunity against cancer by exerting cytotoxicity and secreting a wide variety of cytokines to inhibit tumour progression. Their effector functions are regulated by the integration of opposing signals from activating and inhibitory receptors, which determine NK cell activity against tumour targets. NK cell cytotoxicity requires successful Author: May Sabry, Mark W. Lowdell.